The great thing about NAS is that it basically is a self contained computer that is connected to the network with an IP address. Now of course you can't carry out tasks like a computer workstation, but your able to have a file based storage to all other workstations/servers on the network.
You simply need to set the NAS IP address to be within your LAN IP schema. Than all your workstations/servers will see the NAS on the network, respectively.
I back up specific directories on my servers by using robocopy. I backup the whole server, though, by using Acronis True Image Echo Server, but I think the Windows built-in backup utility can do this too.
As long as you have the NAS path mapped to a drive letter, you should have no issues since Windows will essentially see the NAS as another drive.
Check to see if your NAS came with a backup software. My NAS came with backup software but I chose to use something more robust and enterprise grade.